Searchable abstracts of presentations at key conferences in endocrinology

ea0099oc12.3 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | Part II | ECE2024

Growth hormone promotes in-vivo hepatic triglyceride export in humans

Baumgartner Clemens , Metz Matthaeus , Pfleger Lorenz , Tosin Anna , Beghini Marianna , Beiglboeck Hannes , Fellinger Paul , Schnait Franziska , Vila Greisa , Luger Anton , Kautzky-Willer Alexandra , Freudenthaler Angelika , Baumgartner-Parzer Sabina , Stangl Herbert , Krssak Martin , Scherer Thomas , Krebs Michael , Wolf Peter

Overview: Non-alcoholic fatty liver disease (NAFLD) is defined as a chronic increase in intrahepatic lipids (IHL). A surplus of IHL can be compensated through increased lipid export via very-low density lipoprotein (VLDL) particles. Growth hormone (GH) is known to reduce visceral and ectopic fat. However, the main pathways responsible for the in-vivo decrease of IHL under the influence of GH are yet to be determined.Methods: We assessed hepatic lipid met...